Description
Product Characteristics: KCNQ3, potassium voltage-gated channel, KQT-like subfamily, member 3, BFNC2, EBN2, KV7.3, potassium channel, voltage-gated, subfamily Q, member 3, potassium voltage-gated channel KQT-like protein 3
Target Information: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Two variants encoding distinct isoforms have been found. [provided by RefSeq, Mar 2011]